Proteinuria after Oclacitinib (Apoquel) in dogs

379 reports to the FDA describe proteinuria in dogs given Oclacitinib. That is 1.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

379Reports

37%Marked serious

3.7%Recovered

7.7%Died or euthanised

78 daysTypical onset

How soon it started

Same day

19 7.9%

1–2 days

8 3.3%

3–7 days

11 4.6%

1–4 weeks

42 18%

Over a month

160 67%

How the animals did

Recovered

14 3.7%

Still unwell when reported

290 77%

Died

8 2.1%

Euthanised

21 5.5%

Not known

46 12%

Problems reported at the same time

145 38%

123 32%

76 20%

72 19%

67 18%

62 16%

60 16%

55 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

124

8–11 years

147

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause proteinuria in dogs?: 379 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 78 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Cyclosporine (Atopica) 169 reports · 1.1% of its reports
Proteinuria after Ilunocitinib (Zenrelia) 52 reports · 2.4% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with proteinuria