Proteinuria after Cyclosporine (Atopica) in dogs

The FDA has received 169 reports of proteinuria in dogs after Cyclosporine. That is 1.1% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

169Reports

30%Marked serious

3.0%Recovered

17%Died or euthanised

90 daysTypical onset

How soon it started

Same day

1 2.9%

1–2 days

1 2.9%

3–7 days

1 2.9%

1–4 weeks

8 23%

Over a month

24 69%

How the animals did

Recovered

1 0.6%

Recovered with lasting effects

4 2.4%

Still unwell when reported

24 14%

Died

16 9.5%

Euthanised

12 7.1%

Not known

112 66%

Problems reported at the same time

63 37%

59 35%

49 29%

40 24%

39 23%

35 21%

35 21%

Decreased urine concentration

34 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause proteinuria in dogs?: 169 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 90 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Oclacitinib (Apoquel) 379 reports · 1.3% of its reports
Proteinuria after Ilunocitinib (Zenrelia) 52 reports · 2.4% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with proteinuria