Proteinuria after Ilunocitinib (Zenrelia) in dogs

52 reports to the FDA describe proteinuria in dogs given Ilunocitinib. That is 2.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

52Reports

38%Marked serious

12%Recovered

21%Died or euthanised

83 daysTypical onset

How soon it started

Same day

1 2.6%

1–2 days

3 7.7%

3–7 days

6 15%

1–4 weeks

2 5.1%

Over a month

27 69%

How the animals did

Recovered

6 12%

Still unwell when reported

17 33%

Died

4 7.7%

Euthanised

7 13%

Not known

18 35%

Problems reported at the same time

18 35%

16 31%

15 29%

14 27%

14 27%

14 27%

13 25%

13 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause proteinuria in dogs?: 52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 83 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Oclacitinib (Apoquel) 379 reports · 1.3% of its reports
Proteinuria after Cyclosporine (Atopica) 169 reports · 1.1% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with proteinuria