Kidney problems after Ilunocitinib (Zenrelia) in dogs

The FDA has received 86 reports of kidney problems in dogs after Ilunocitinib. That is 3.9% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

86Reports

65%Marked serious

13%Recovered

27%Died or euthanised

83 daysTypical onset

How soon it started

Same day

3 4.8%

1–2 days

4 6.5%

3–7 days

6 9.7%

1–4 weeks

4 6.5%

Over a month

45 73%

How the animals did

Recovered

11 13%

Still unwell when reported

19 22%

Died

3 3.5%

Euthanised

20 23%

Not known

33 38%

Problems reported at the same time

41 48%

34 40%

30 35%

26 30%

23 27%

23 27%

19 22%

18 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause kidney problems in dogs?: 86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 83 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Oclacitinib (Apoquel) 981 reports · 3.4% of its reports
Kidney problems after Cyclosporine (Atopica) 411 reports · 2.7% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with kidney problems