Hypoalbuminaemia after Oclacitinib (Apoquel) in dogs

424 reports to the FDA describe hypoalbuminaemia in dogs given Oclacitinib. That is 1.5% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

424Reports

43%Marked serious

4.0%Recovered

15%Died or euthanised

82 daysTypical onset

How soon it started

Same day

24 9.1%

1–2 days

12 4.5%

3–7 days

4 1.5%

1–4 weeks

46 17%

Over a month

178 67%

How the animals did

Recovered

17 4.0%

Still unwell when reported

310 73%

Died

16 3.8%

Euthanised

47 11%

Not known

34 8.0%

Problems reported at the same time

126 30%

111 26%

107 25%

102 24%

97 23%

93 22%

85 20%

76 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

171

8–11 years

162

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause hypoalbuminaemia in dogs?: 424 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 82 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoalbuminaemia with similar medicines

Hypoalbuminaemia after Cyclosporine (Atopica) 204 reports · 1.3% of its reports
Hypoalbuminaemia after Ilunocitinib (Zenrelia) 53 reports · 2.4% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with hypoalbuminaemia