Hypoproteinaemia after Oclacitinib (Apoquel) in dogs

203 reports to the FDA describe hypoproteinaemia in dogs given Oclacitinib. That is 0.7% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

203Reports

43%Marked serious

6.9%Recovered

14%Died or euthanised

87 daysTypical onset

How soon it started

Same day

14 10%

1–2 days

5 3.6%

3–7 days

3 2.1%

1–4 weeks

17 12%

Over a month

101 72%

How the animals did

Recovered

14 6.9%

Still unwell when reported

146 72%

Died

7 3.4%

Euthanised

22 11%

Not known

14 6.9%

Problems reported at the same time

126 62%

64 32%

62 31%

57 28%

51 25%

47 23%

47 23%

45 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause hypoproteinaemia in dogs?: 203 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 87 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoproteinaemia with similar medicines

Hypoproteinaemia after Cyclosporine (Atopica) 61 reports · 0.4% of its reports
Hypoproteinaemia after Ilunocitinib (Zenrelia) 36 reports · 1.6% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with hypoproteinaemia