Loose stool after Oclacitinib (Apoquel) in dogs

284 reports to the FDA describe loose stool in dogs given Oclacitinib. That is 1.0% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

284Reports

33%Marked serious

14%Recovered

8.8%Died or euthanised

14 daysTypical onset

How soon it started

Same day

48 20%

1–2 days

32 13%

3–7 days

23 9.7%

1–4 weeks

42 18%

Over a month

93 39%

How the animals did

Recovered

41 14%

Still unwell when reported

160 56%

Died

4 1.4%

Euthanised

21 7.4%

Not known

58 20%

Problems reported at the same time

Vomiting

117 41%

Loss of appetite

95 33%

Lethargy

90 32%

Didn't work as expected

55 19%

53 19%

40 14%

32 11%

25 8.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause loose stool in dogs?: 284 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loose stool with similar medicines

Loose stool after Cyclosporine (Atopica) 341 reports · 2.2% of its reports
Loose stool after Ilunocitinib (Zenrelia) 25 reports · 1.1% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with loose stool