Loose stool after Ilunocitinib (Zenrelia) in dogs

25 reports to the FDA describe loose stool in dogs given Ilunocitinib. That is 1.1% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

25Reports

32%Marked serious

8.0%Recovered

20%Died or euthanised

76 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

2 8.7%

3–7 days

3 13%

1–4 weeks

3 13%

Over a month

15 65%

How the animals did

Recovered

2 8.0%

Still unwell when reported

11 44%

Died

1 4.0%

Euthanised

4 16%

Not known

7 28%

Problems reported at the same time

Loss of appetite

10 40%

Vomiting

9 36%

Liver problems

6 24%

Didn't work as expected

6 24%

Death

5 20%

Lethargy

5 20%

Diarrhea

5 20%

Tense abdomen

4 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause loose stool in dogs?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 76 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loose stool with similar medicines

Loose stool after Oclacitinib (Apoquel) 284 reports · 1.0% of its reports
Loose stool after Cyclosporine (Atopica) 341 reports · 2.2% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with loose stool