Inappropriate urination after Oclacitinib (Apoquel) in dogs

The FDA has received 283 reports of inappropriate urination in dogs after Oclacitinib. That is 1.0% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

283Reports
41%Marked serious
16%Recovered
11%Died or euthanised
17 daysTypical onset
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How soon it started

Same day
39 18%
1–2 days
25 11%
3–7 days
21 9.5%
1–4 weeks
47 21%
Over a month
90 41%

How the animals did

Recovered
44 16%
Still unwell when reported
172 61%
Died
9 3.2%
Euthanised
23 8.1%
Not known
35 12%

Problems reported at the same time

Loss of appetite
56 20%
Excessive thirst
54 19%
Excessive urination
47 17%
Vomiting
46 16%
Liver problems
44 16%
Lethargy
37 13%
Urinary tract infection
36 13%
Behaviour change
33 12%

Age of the animals

Under 1 year
1
1–3 years
51
4–7 years
83
8–11 years
90
12+ years
56

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause inappropriate urination in dogs?
283 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 17 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate urination with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with inappropriate urination