Blood in faeces after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

51 reports to the FDA describe blood in faeces in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.5% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

51Reports

90%Marked serious

31%Recovered

2.0%Died or euthanised

6 daysTypical onset

How soon it started

Same day

8 22%

1–2 days

8 22%

3–7 days

4 11%

1–4 weeks

14 38%

Over a month

3 8.1%

How the animals did

Recovered

16 31%

Still unwell when reported

6 12%

Euthanised

1 2.0%

Not known

28 55%

Problems reported at the same time

Diarrhea

27 53%

Vomiting

20 39%

Didn't work as expected

19 37%

17 33%

13 25%

10 20%

9 18%

Digestive tract disorder

3 5.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause blood in faeces in dogs?: 51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood in faeces with similar medicines

Blood in faeces after Spinosad (Comfortis) 49 reports · 0.1% of its reports
Blood in faeces after Lufenuron + Milbemycin Oxime (Sentinel) 99 reports · 0.4% of its reports
Blood in faeces after Imidacloprid + Moxidectin (Advantage Multi) 50 reports · 0.4% of its reports
Blood in faeces after Nitenpyram (Capstar) 21 reports · 0.2% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with blood in faeces