Mucous stool after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 26 reports of mucous stool in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

26Reports

62%Marked serious

38%Recovered

3.8%Died or euthanised

10 daysTypical onset

How soon it started

Same day

4 20%

1–2 days

2 10%

3–7 days

4 20%

1–4 weeks

6 30%

Over a month

4 20%

How the animals did

Recovered

10 38%

Still unwell when reported

3 12%

Died

1 3.8%

Not known

12 46%

Problems reported at the same time

Didn't stop worms

13 50%

Diarrhea

11 42%

Blood in faeces

9 35%

Didn't work as expected

8 31%

6 23%

5 19%

3 12%

2 7.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause mucous stool in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Mucous stool with similar medicines

Mucous stool after Spinosad (Comfortis) 40 reports · 0.1% of its reports
Mucous stool after Lufenuron + Milbemycin Oxime (Sentinel) 90 reports · 0.3% of its reports
Mucous stool after Imidacloprid + Moxidectin (Advantage Multi) 54 reports · 0.4% of its reports
Mucous stool after Nitenpyram (Capstar) 22 reports · 0.2% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with mucous stool