Urine abnormalities after Leptospirosis Vaccine in dogs

The FDA has received 103 reports of urine abnormalities in dogs after Leptospirosis Vaccine. That is 1.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

103Reports
59%Marked serious
4.9%Recovered
20%Died or euthanised
5 daysTypical onset
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How soon it started

Same day
14 20%
1–2 days
15 21%
3–7 days
9 13%
1–4 weeks
9 13%
Over a month
24 34%

How the animals did

Recovered
5 4.9%
Still unwell when reported
44 43%
Died
7 6.8%
Euthanised
14 14%
Not known
33 32%

Problems reported at the same time

Liver problems
54 52%
Lethargy
46 45%
Loss of appetite
41 40%
Vomiting
41 40%
Kidney problems
40 39%
Proteinuria
38 37%
Didn't work as expected
36 35%
Blood problems
25 24%

Age of the animals

Under 1 year
14
1–3 years
16
4–7 years
28
8–11 years
31
12+ years
14

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause urine abnormalities in dogs?
103 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 5 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urine abnormalities with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with urine abnormalities