Urine abnormalities after Lyme Vaccine in dogs

The FDA has received 49 reports of urine abnormalities in dogs after Lyme Vaccine. That is 0.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

49Reports
51%Marked serious
4.1%Recovered
14%Died or euthanised
68 daysTypical onset
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How soon it started

Same day
3 12%
1–2 days
2 7.7%
3–7 days
2 7.7%
1–4 weeks
6 23%
Over a month
13 50%

How the animals did

Recovered
2 4.1%
Still unwell when reported
21 43%
Died
1 2.0%
Euthanised
6 12%
Not known
19 39%

Problems reported at the same time

Didn't work as expected
28 57%
Liver problems
20 41%
Proteinuria
19 39%
Kidney problems
17 35%
Haematuria
16 33%
Didn't stop ticks
15 31%
Lethargy
14 29%
Loss of appetite
13 27%

Age of the animals

Under 1 year
4
1–3 years
21
4–7 years
11
8–11 years
12
12+ years
1

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Lyme Vaccine cause urine abnormalities in dogs?
49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 68 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urine abnormalities with similar medicines

All reported side effects of Lyme Vaccine in dogs · Medicines most reported with urine abnormalities