Restlessness or agitation after Leptospirosis Vaccine in dogs

The FDA has received 151 reports of restlessness or agitation in dogs after Leptospirosis Vaccine. That is 1.9% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

151Reports
52%Marked serious
36%Recovered
8.6%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
73 54%
1–2 days
19 14%
3–7 days
8 6.0%
1–4 weeks
15 11%
Over a month
19 14%

How the animals did

Recovered
53 35%
Recovered with lasting effects
2 1.3%
Still unwell when reported
54 36%
Died
3 2.0%
Euthanised
10 6.6%
Not known
29 19%

Problems reported at the same time

Age of the animals

Under 1 year
17
1–3 years
44
4–7 years
38
8–11 years
28
12+ years
24

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause restlessness or agitation in dogs?
151 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with restlessness or agitation