Inappropriate urination after Leptospirosis Vaccine in dogs

The FDA has received 109 reports of inappropriate urination in dogs after Leptospirosis Vaccine. That is 1.4% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

109Reports
67%Marked serious
24%Recovered
20%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
36 40%
1–2 days
21 24%
3–7 days
5 5.6%
1–4 weeks
12 13%
Over a month
15 17%

How the animals did

Recovered
25 23%
Recovered with lasting effects
1 0.9%
Still unwell when reported
47 43%
Died
10 9.2%
Euthanised
12 11%
Not known
14 13%

Problems reported at the same time

Age of the animals

Under 1 year
21
1–3 years
24
4–7 years
19
8–11 years
20
12+ years
21

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause inappropriate urination in dogs?
109 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate urination with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with inappropriate urination