Inappropriate defecation after Leptospirosis Vaccine in dogs

The FDA has received 56 reports of inappropriate defecation in dogs after Leptospirosis Vaccine. That is 0.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

56Reports
82%Marked serious
30%Recovered
20%Died or euthanised
Same dayTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
26 53%
1–2 days
5 10%
3–7 days
3 6.1%
1–4 weeks
5 10%
Over a month
10 20%

How the animals did

Recovered
17 30%
Still unwell when reported
22 39%
Died
8 14%
Euthanised
3 5.4%
Not known
6 11%

Problems reported at the same time

Vomiting
34 61%
Lethargy
23 41%
Allergic reaction
21 38%
Inappropriate urination
20 36%
Pale mucous membrane
17 30%
Liver problems
16 29%
Breathing problems
15 27%
Death
11 20%

Age of the animals

Under 1 year
3
1–3 years
21
4–7 years
10
8–11 years
9
12+ years
13

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause inappropriate defecation in dogs?
56 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate defecation with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with inappropriate defecation