Hypoalbuminaemia after Leptospirosis Vaccine in dogs

The FDA has received 125 reports of hypoalbuminaemia in dogs after Leptospirosis Vaccine. That is 1.6% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

125Reports
82%Marked serious
11%Recovered
40%Died or euthanised
16 daysTypical onset
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How soon it started

Same day
24 25%
1–2 days
11 12%
3–7 days
7 7.4%
1–4 weeks
19 20%
Over a month
34 36%

How the animals did

Recovered
14 11%
Still unwell when reported
43 34%
Died
18 14%
Euthanised
32 26%
Not known
18 14%

Problems reported at the same time

Age of the animals

Under 1 year
19
1–3 years
22
4–7 years
43
8–11 years
29
12+ years
12

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause hypoalbuminaemia in dogs?
125 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 16 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoalbuminaemia with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with hypoalbuminaemia