Hyperproteinaemia after Leptospirosis Vaccine in dogs

55 reports to the FDA describe hyperproteinaemia in dogs given Leptospirosis Vaccine. That is 0.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

55Reports

67%Marked serious

7.3%Recovered

22%Died or euthanised

9 daysTypical onset

How soon it started

Same day

10 21%

1–2 days

8 17%

3–7 days

4 8.5%

1–4 weeks

15 32%

Over a month

10 21%

How the animals did

Recovered

2 3.6%

Recovered with lasting effects

2 3.6%

Still unwell when reported

24 44%

Died

3 5.5%

Euthanised

9 16%

Not known

15 27%

Problems reported at the same time

30 55%

24 44%

23 42%

22 40%

20 36%

19 35%

18 33%

18 33%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause hyperproteinaemia in dogs?: 55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperproteinaemia with similar medicines

Hyperproteinaemia after Rabies Vaccine 52 reports · 0.5% of its reports
Hyperproteinaemia after Bordetella Vaccine 44 reports · 0.5% of its reports
Hyperproteinaemia after Distemper-parvo Vaccine 25 reports · 0.4% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with hyperproteinaemia