Elevated symmetrical dimethylarginine (sdma) after Leptospirosis Vaccine in dogs

44 reports to the FDA describe elevated symmetrical dimethylarginine (sdma) in dogs given Leptospirosis Vaccine. That is 0.5% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

44Reports
75%Marked serious
6.8%Recovered
25%Died or euthanised
34 daysTypical onset
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How soon it started

Same day
4 13%
1–2 days
7 23%
3–7 days
0 0.0%
1–4 weeks
4 13%
Over a month
16 52%

How the animals did

Recovered
3 6.8%
Still unwell when reported
25 57%
Euthanised
11 25%
Not known
5 11%

Problems reported at the same time

Kidney problems
35 80%
Loss of appetite
26 59%
Liver problems
24 55%
Didn't work as expected
17 39%
Lethargy
15 34%
Proteinuria
15 34%
Vomiting
14 32%
Hyperphosphataemia
14 32%

Age of the animals

Under 1 year
5
1–3 years
8
4–7 years
13
8–11 years
9
12+ years
9

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause elevated symmetrical dimethylarginine (sdma) in dogs?
44 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 34 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated symmetrical dimethylarginine (sdma) with similar medicines

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with elevated symmetrical dimethylarginine (sdma)