Elevated symmetrical dimethylarginine (sdma) after Rabies Vaccine in dogs

The FDA has received 44 reports of elevated symmetrical dimethylarginine (sdma) in dogs after Rabies Vaccine. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

44Reports

89%Marked serious

6.8%Recovered

48%Died or euthanised

11 daysTypical onset

How soon it started

Same day

4 9.8%

1–2 days

7 17%

3–7 days

8 20%

1–4 weeks

9 22%

Over a month

13 32%

How the animals did

Recovered

2 4.5%

Recovered with lasting effects

1 2.3%

Still unwell when reported

17 39%

Died

2 4.5%

Euthanised

19 43%

Not known

3 6.8%

Problems reported at the same time

35 80%

27 61%

23 52%

21 48%

21 48%

19 43%

16 36%

13 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Rabies Vaccine cause elevated symmetrical dimethylarginine (sdma) in dogs?: 44 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated symmetrical dimethylarginine (sdma) with similar medicines

Elevated symmetrical dimethylarginine (sdma) after Bordetella Vaccine 46 reports · 0.5% of its reports
Elevated symmetrical dimethylarginine (sdma) after Leptospirosis Vaccine 44 reports · 0.5% of its reports

All reported side effects of Rabies Vaccine in dogs · Medicines most reported with elevated symmetrical dimethylarginine (sdma)