Liver problems after Hydroxyzine in dogs

90 reports to the FDA describe liver problems in dogs given Hydroxyzine. That is 8.7% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

90Reports
56%Marked serious
22%Recovered
7.8%Died or euthanised
92 daysTypical onset
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How soon it started

Same day
5 8.3%
1–2 days
2 3.3%
3–7 days
3 5.0%
1–4 weeks
10 17%
Over a month
40 67%

How the animals did

Recovered
16 18%
Recovered with lasting effects
4 4.4%
Still unwell when reported
43 48%
Died
1 1.1%
Euthanised
6 6.7%
Not known
20 22%

Problems reported at the same time

32 36%
29 32%
18 20%
Abnormal ultrasound finding
11 12%
Elevated cholesterol (total)
11 12%

Age of the animals

Under 1 year
1
1–3 years
11
4–7 years
21
8–11 years
39
12+ years
17

About this medicine

Type: medicine.

Questions owners ask

Can Hydroxyzine cause liver problems in dogs?
90 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 92 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Hydroxyzine in dogs · Medicines most reported with liver problems