Hypochloraemia after Doxycycline in dogs

24 reports to the FDA describe hypochloraemia in dogs given Doxycycline. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

88%Marked serious

13%Recovered

42%Died or euthanised

27 daysTypical onset

How soon it started

Same day

3 15%

1–2 days

3 15%

3–7 days

0 0.0%

1–4 weeks

5 25%

Over a month

9 45%

How the animals did

Recovered

2 8.3%

Recovered with lasting effects

1 4.2%

Still unwell when reported

6 25%

Euthanised

10 42%

Not known

5 21%

Problems reported at the same time

21 88%

15 63%

12 50%

12 50%

12 50%

11 46%

11 46%

10 42%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause hypochloraemia in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 27 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypochloraemia with similar medicines

Hypochloraemia after Amoxicillin + Clavulanate (Clavamox) 52 reports · 1.0% of its reports
Hypochloraemia after Cefovecin (Convenia) 28 reports · 0.7% of its reports
Hypochloraemia after Enrofloxacin (Baytril) 40 reports · 1.1% of its reports
Hypochloraemia after Metronidazole 47 reports · 1.5% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with hypochloraemia