Hypochloraemia after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 52 reports of hypochloraemia in dogs after Amoxicillin + Clavulanate. That is 1.0% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

52Reports
77%Marked serious
9.6%Recovered
35%Died or euthanised
17 daysTypical onset
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How soon it started

Same day
6 14%
1–2 days
2 4.8%
3–7 days
9 21%
1–4 weeks
8 19%
Over a month
17 40%

How the animals did

Recovered
5 9.6%
Still unwell when reported
19 37%
Died
12 23%
Euthanised
6 12%
Not known
10 19%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
12
4–7 years
14
8–11 years
14
12+ years
11

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause hypochloraemia in dogs?
52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 17 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypochloraemia with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with hypochloraemia