Eosinopenia after Doxycycline in dogs

The FDA has received 42 reports of eosinopenia in dogs after Doxycycline. That is 1.0% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

42Reports

90%Marked serious

4.8%Recovered

43%Died or euthanised

16 daysTypical onset

How soon it started

Same day

3 8.6%

1–2 days

4 11%

3–7 days

7 20%

1–4 weeks

6 17%

Over a month

15 43%

How the animals did

Recovered

2 4.8%

Still unwell when reported

15 36%

Died

7 17%

Euthanised

11 26%

Not known

7 17%

Problems reported at the same time

25 60%

25 60%

22 52%

21 50%

20 48%

19 45%

18 43%

17 40%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause eosinopenia in dogs?: 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eosinopenia with similar medicines

Eosinopenia after Amoxicillin + Clavulanate (Clavamox) 38 reports · 0.7% of its reports
Eosinopenia after Enrofloxacin (Baytril) 31 reports · 0.8% of its reports
Eosinopenia after Metronidazole 47 reports · 1.5% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with eosinopenia