Unresponsive after Diphenhydramine in dogs

The FDA has received 60 reports of unresponsive in dogs after Diphenhydramine. That is 1.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

60Reports
95%Marked serious
17%Recovered
42%Died or euthanised
Same dayTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
31 58%
1–2 days
6 11%
3–7 days
3 5.7%
1–4 weeks
4 7.5%
Over a month
9 17%

How the animals did

Recovered
8 13%
Recovered with lasting effects
2 3.3%
Still unwell when reported
20 33%
Died
17 28%
Euthanised
8 13%
Not known
5 8.3%

Problems reported at the same time

Age of the animals

Under 1 year
8
1–3 years
21
4–7 years
11
8–11 years
13
12+ years
7

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause unresponsive in dogs?
60 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unresponsive with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with unresponsive