Collapse after Diphenhydramine in dogs

230 reports to the FDA describe collapse in dogs given Diphenhydramine. That is 4.9% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

230Reports
93%Marked serious
25%Recovered
30%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
166 80%
1–2 days
4 1.9%
3–7 days
8 3.8%
1–4 weeks
7 3.4%
Over a month
23 11%

How the animals did

Recovered
56 24%
Recovered with lasting effects
2 0.9%
Still unwell when reported
96 42%
Died
39 17%
Euthanised
29 13%
Not known
8 3.5%

Problems reported at the same time

Age of the animals

Under 1 year
23
1–3 years
95
4–7 years
40
8–11 years
48
12+ years
23

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause collapse in dogs?
230 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with collapse