Collapse after Melarsomine (Immiticide) in dogs

The FDA has received 679 reports of collapse in dogs after Melarsomine. That is 3.0% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

679Reports

53%Marked serious

16%Recovered

15%Died or euthanised

6 daysTypical onset

How soon it started

Same day

128 35%

1–2 days

15 4.1%

3–7 days

65 18%

1–4 weeks

69 19%

Over a month

91 25%

How the animals did

Recovered

102 15%

Recovered with lasting effects

4 0.6%

Still unwell when reported

155 23%

Died

92 14%

Euthanised

12 1.8%

Not known

314 46%

Problems reported at the same time

282 42%

184 27%

154 23%

121 18%

107 16%

105 15%

101 15%

99 15%

Age of the animals

Under 1 year

1–3 years

332

4–7 years

220

8–11 years

12+ years

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause collapse in dogs?: 679 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Polysulfated Glycosaminoglycan 129 reports · 2.4% of its reports
Collapse after Diphenhydramine 230 reports · 4.9% of its reports
Collapse after Butorphanol 103 reports · 2.3% of its reports
Collapse after Cefpodoxime 71 reports · 1.8% of its reports
Collapse after Tramadol 110 reports · 2.9% of its reports
Collapse after Florfenicol + Mometasone + Terbinafine 35 reports · 1.0% of its reports
Collapse after Desoxycorticosterone Pivalate 98 reports · 2.9% of its reports
Collapse after Propofol 46 reports · 1.5% of its reports
Collapse after Isoflurane 48 reports · 1.7% of its reports
Collapse after Cephalexin 34 reports · 1.3% of its reports

All reported side effects of Melarsomine in dogs · Medicines most reported with collapse