Malaise after Diphenhydramine in dogs

The FDA has received 48 reports of malaise in dogs after Diphenhydramine. That is 1.0% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

48Reports
50%Marked serious
21%Recovered
19%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
15 42%
1–2 days
5 14%
3–7 days
3 8.3%
1–4 weeks
4 11%
Over a month
9 25%

How the animals did

Recovered
10 21%
Still unwell when reported
19 40%
Died
4 8.3%
Euthanised
5 10%
Not known
10 21%

Problems reported at the same time

Age of the animals

Under 1 year
6
1–3 years
10
4–7 years
13
8–11 years
13
12+ years
6

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause malaise in dogs?
48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Malaise with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with malaise