Pale mucous membrane after Cyclosporine (Atopica) in dogs

The FDA has received 185 reports of pale mucous membrane in dogs after Cyclosporine. That is 1.2% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

185Reports
51%Marked serious
16%Recovered
28%Died or euthanised
15 daysTypical onset
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How soon it started

Same day
18 26%
1–2 days
5 7.1%
3–7 days
8 11%
1–4 weeks
15 21%
Over a month
24 34%

How the animals did

Recovered
29 16%
Recovered with lasting effects
1 0.5%
Still unwell when reported
15 8.1%
Died
18 9.7%
Euthanised
34 18%
Not known
88 48%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
59
4–7 years
66
8–11 years
41
12+ years
16

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause pale mucous membrane in dogs?
185 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 15 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

All reported side effects of Cyclosporine in dogs · Medicines most reported with pale mucous membrane