Leucopenia after Cyclosporine (Atopica) in dogs

The FDA has received 131 reports of leucopenia in dogs after Cyclosporine. That is 0.9% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

131Reports

24%Marked serious

3.1%Recovered

18%Died or euthanised

39 daysTypical onset

How soon it started

Same day

3 8.8%

1–2 days

2 5.9%

3–7 days

1 2.9%

1–4 weeks

8 24%

Over a month

20 59%

How the animals did

Recovered

4 3.1%

Still unwell when reported

24 18%

Died

17 13%

Euthanised

7 5.3%

Not known

79 60%

Problems reported at the same time

46 35%

42 32%

38 29%

37 28%

36 27%

32 24%

24 18%

24 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause leucopenia in dogs?: 131 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 39 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucopenia with similar medicines

Leucopenia after Oclacitinib (Apoquel) 856 reports · 3.0% of its reports
Leucopenia after Ilunocitinib (Zenrelia) 86 reports · 3.9% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with leucopenia