Leucopenia after Ilunocitinib (Zenrelia) in dogs

86 reports to the FDA describe leucopenia in dogs given Ilunocitinib. That is 3.9% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

86Reports
23%Marked serious
20%Recovered
8.1%Died or euthanised
50 daysTypical onset
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How soon it started

Same day
4 5.1%
1–2 days
4 5.1%
3–7 days
0 0.0%
1–4 weeks
17 22%
Over a month
54 68%

How the animals did

Recovered
17 20%
Still unwell when reported
29 34%
Died
3 3.5%
Euthanised
4 4.7%
Not known
33 38%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
8
4–7 years
42
8–11 years
28
12+ years
3

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause leucopenia in dogs?
86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 50 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucopenia with similar medicines

All reported side effects of Ilunocitinib in dogs · Medicines most reported with leucopenia