Neutropenia after Cyclosporine (Atopica) in dogs

60 reports to the FDA describe neutropenia in dogs given Cyclosporine. That is 0.4% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

60Reports

35%Marked serious

0.0%Recovered

25%Died or euthanised

78 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

0 0.0%

3–7 days

6 23%

1–4 weeks

4 15%

Over a month

16 62%

How the animals did

Still unwell when reported

17 28%

Died

8 13%

Euthanised

7 12%

Not known

28 47%

Problems reported at the same time

32 53%

21 35%

20 33%

16 27%

16 27%

16 27%

15 25%

15 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause neutropenia in dogs?: 60 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 78 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutropenia with similar medicines

Neutropenia after Oclacitinib (Apoquel) 642 reports · 2.2% of its reports
Neutropenia after Ilunocitinib (Zenrelia) 218 reports · 9.9% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with neutropenia