Seizures after Emodepside + Praziquantel (Profender) in cats

The FDA has received 100 reports of seizures in cats after Emodepside + Praziquantel. That is 1.7% of all reports for this medicine, compared with 2.6% across reports for all cat medicines, so it is reported less often than average with this medicine.

100Reports
79%Marked serious
26%Recovered
30%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
40 52%
1–2 days
22 29%
3–7 days
10 13%
1–4 weeks
2 2.6%
Over a month
3 3.9%

How the animals did

Recovered
25 25%
Recovered with lasting effects
1 1.0%
Still unwell when reported
13 13%
Died
19 19%
Euthanised
11 11%
Not known
31 31%

Problems reported at the same time

Age of the animals

Under 1 year
34
1–3 years
29
4–7 years
14
8–11 years
13
12+ years
7

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause seizures in cats?
100 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with seizures