Seizures after Praziquantel + Pyrantel in cats

The FDA has received 25 reports of seizures in cats after Praziquantel + Pyrantel. That is 2.0% of all reports for this medicine, compared with 2.6% across reports for all cat medicines.

25Reports

72%Marked serious

24%Recovered

16%Died or euthanised

Same dayTypical onset

How soon it started

Same day

10 63%

1–2 days

4 25%

3–7 days

0 0.0%

1–4 weeks

2 13%

Over a month

0 0.0%

How the animals did

Recovered

6 24%

Still unwell when reported

2 8.0%

Died

1 4.0%

Euthanised

3 12%

Not known

13 52%

Problems reported at the same time

10 40%

9 36%

6 24%

5 20%

5 20%

4 16%

4 16%

Lateral recumbency

4 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause seizures in cats?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Emodepside + Praziquantel (Profender) 100 reports · 1.7% of its reports
Seizures after Praziquantel 24 reports · 1.4% of its reports
Seizures after Pyrantel 24 reports · 4.3% of its reports

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with seizures