Liver problems after Tylosin in dogs

50 reports to the FDA describe liver problems in dogs given Tylosin. That is 7.8% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

50Reports
36%Marked serious
10%Recovered
18%Died or euthanised
43 daysTypical onset
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How soon it started

Same day
6 27%
1–2 days
1 4.5%
3–7 days
1 4.5%
1–4 weeks
2 9.1%
Over a month
12 55%

How the animals did

Recovered
1 2.0%
Recovered with lasting effects
4 8.0%
Still unwell when reported
17 34%
Died
5 10%
Euthanised
4 8.0%
Not known
19 38%

Problems reported at the same time

13 26%
12 24%
9 18%
Elevated cholesterol (total)
6 12%
Splenomegaly
5 10%
Kidney problems
5 10%

Age of the animals

Under 1 year
1
1–3 years
9
4–7 years
6
8–11 years
18
12+ years
14

About this medicine

Type: medicine.

Questions owners ask

Can Tylosin cause liver problems in dogs?
50 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 43 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Tylosin in dogs · Medicines most reported with liver problems