Walking difficulty after Trilostane (Vetoryl) in dogs

The FDA has received 96 reports of walking difficulty in dogs after Trilostane. That is 0.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

96Reports
75%Marked serious
20%Recovered
20%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
4 5.1%
1–2 days
6 7.7%
3–7 days
10 13%
1–4 weeks
17 22%
Over a month
41 53%

How the animals did

Recovered
18 19%
Recovered with lasting effects
1 1.0%
Still unwell when reported
19 20%
Died
2 2.1%
Euthanised
17 18%
Not known
39 41%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
6
8–11 years
42
12+ years
47

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause walking difficulty in dogs?
96 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Walking difficulty with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with walking difficulty