Uncoded sign after Trilostane (Vetoryl) in dogs

The FDA has received 181 reports of uncoded sign in dogs after Trilostane. That is 1.5% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

181Reports

70%Marked serious

24%Recovered

19%Died or euthanised

33 daysTypical onset

How soon it started

Same day

15 9.6%

1–2 days

11 7.1%

3–7 days

13 8.3%

1–4 weeks

36 23%

Over a month

81 52%

How the animals did

Recovered

41 23%

Recovered with lasting effects

2 1.1%

Still unwell when reported

24 13%

Died

7 3.9%

Euthanised

27 15%

Not known

80 44%

Problems reported at the same time

67 37%

63 35%

52 29%

47 26%

44 24%

39 22%

38 21%

37 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause uncoded sign in dogs?: 181 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 33 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Uncoded sign with similar medicines

Uncoded sign after Insulin 39 reports · 0.5% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with uncoded sign