Unable to rise after Trilostane (Vetoryl) in dogs

53 reports to the FDA describe unable to rise in dogs given Trilostane. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

53Reports
74%Marked serious
13%Recovered
26%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
4 9.8%
1–2 days
5 12%
3–7 days
4 9.8%
1–4 weeks
6 15%
Over a month
22 54%

How the animals did

Recovered
5 9.4%
Recovered with lasting effects
2 3.8%
Still unwell when reported
8 15%
Died
1 1.9%
Euthanised
13 25%
Not known
24 45%

Problems reported at the same time

Loss of appetite
28 53%
Lethargy
23 43%
Vomiting
18 34%
Weakness
16 30%
Death
13 25%
Abnormal ultrasound finding
11 21%
Liver problems
10 19%
Breathing problems
10 19%

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
1
8–11 years
31
12+ years
19

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause unable to rise in dogs?
53 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unable to rise with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with unable to rise