Lymphopenia after Trilostane (Vetoryl) in dogs

117 reports to the FDA describe lymphopenia in dogs given Trilostane. That is 1.0% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

117Reports

63%Marked serious

2.6%Recovered

14%Died or euthanised

89 daysTypical onset

How soon it started

Same day

3 3.4%

1–2 days

1 1.1%

3–7 days

3 3.4%

1–4 weeks

17 19%

Over a month

64 73%

How the animals did

Recovered

3 2.6%

Still unwell when reported

31 26%

Died

2 1.7%

Euthanised

14 12%

Not known

67 57%

Problems reported at the same time

79 68%

42 36%

41 35%

39 33%

32 27%

31 26%

26 22%

25 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause lymphopenia in dogs?: 117 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 89 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with lymphopenia