Hypoproteinaemia after Trilostane (Vetoryl) in dogs

The FDA has received 30 reports of hypoproteinaemia in dogs after Trilostane. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

30Reports

77%Marked serious

3.3%Recovered

37%Died or euthanised

141 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

1 5.6%

3–7 days

1 5.6%

1–4 weeks

5 28%

Over a month

11 61%

How the animals did

Recovered

1 3.3%

Still unwell when reported

6 20%

Euthanised

11 37%

Not known

12 40%

Problems reported at the same time

19 63%

15 50%

15 50%

14 47%

14 47%

11 37%

11 37%

10 33%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause hypoproteinaemia in dogs?: 30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 141 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with hypoproteinaemia