Hair loss after Trilostane (Vetoryl) in dogs

The FDA has received 380 reports of hair loss in dogs after Trilostane. That is 3.2% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

380Reports
48%Marked serious
7.4%Recovered
7.1%Died or euthanised
53 daysTypical onset
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How soon it started

Same day
11 3.6%
1–2 days
8 2.6%
3–7 days
17 5.6%
1–4 weeks
64 21%
Over a month
202 67%

How the animals did

Recovered
25 6.6%
Recovered with lasting effects
3 0.8%
Still unwell when reported
59 16%
Died
8 2.1%
Euthanised
19 5.0%
Not known
266 70%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
56
8–11 years
189
12+ years
121

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause hair loss in dogs?
380 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 53 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hair loss with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with hair loss