Gall bladder & bile duct disorder after Trilostane (Vetoryl) in dogs

The FDA has received 137 reports of gall bladder & bile duct disorder in dogs after Trilostane. That is 1.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

137Reports
80%Marked serious
2.9%Recovered
18%Died or euthanised
75 daysTypical onset
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How soon it started

Same day
2 2.0%
1–2 days
2 2.0%
3–7 days
7 6.9%
1–4 weeks
23 23%
Over a month
68 67%

How the animals did

Recovered
4 2.9%
Still unwell when reported
42 31%
Died
8 5.8%
Euthanised
17 12%
Not known
66 48%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
9
8–11 years
70
12+ years
53

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause gall bladder & bile duct disorder in dogs?
137 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 75 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Gall bladder & bile duct disorder with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with gall bladder & bile duct disorder