Enlarged liver after Trilostane (Vetoryl) in dogs

88 reports to the FDA describe enlarged liver in dogs given Trilostane. That is 0.7% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

88Reports

64%Marked serious

1.1%Recovered

23%Died or euthanised

85 daysTypical onset

How soon it started

Same day

2 3.0%

1–2 days

0 0.0%

3–7 days

2 3.0%

1–4 weeks

22 33%

Over a month

41 61%

How the animals did

Recovered

1 1.1%

Still unwell when reported

16 18%

Died

8 9.1%

Euthanised

12 14%

Not known

51 58%

Problems reported at the same time

Liver problems

56 64%

Abnormal ultrasound finding

42 48%

Kidney problems

36 41%

Loss of appetite

28 32%

Lethargy

23 26%

Abnormal radiograph finding

22 25%

Elevated gamma-glutamyl transferase (ggt)

21 24%

Breathing problems

20 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause enlarged liver in dogs?: 88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 85 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with enlarged liver