Elevated cholesterol (total) after Trilostane (Vetoryl) in dogs

312 reports to the FDA describe elevated cholesterol (total) in dogs given Trilostane. That is 2.6% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

312Reports
50%Marked serious
2.6%Recovered
9.9%Died or euthanised
89 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
8 3.5%
1–2 days
3 1.3%
3–7 days
16 7.0%
1–4 weeks
50 22%
Over a month
151 66%

How the animals did

Recovered
3 1.0%
Recovered with lasting effects
5 1.6%
Still unwell when reported
56 18%
Died
7 2.2%
Euthanised
24 7.7%
Not known
217 70%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
35
8–11 years
157
12+ years
112

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause elevated cholesterol (total) in dogs?
312 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 89 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated cholesterol (total) with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with elevated cholesterol (total)