Decreased activity after Trilostane (Vetoryl) in dogs

114 reports to the FDA describe decreased activity in dogs given Trilostane. That is 1.0% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

114Reports
52%Marked serious
12%Recovered
15%Died or euthanised
59 daysTypical onset
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How soon it started

Same day
3 3.1%
1–2 days
6 6.3%
3–7 days
7 7.3%
1–4 weeks
17 18%
Over a month
63 66%

How the animals did

Recovered
13 11%
Recovered with lasting effects
1 0.9%
Still unwell when reported
12 11%
Died
5 4.4%
Euthanised
12 11%
Not known
71 62%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
10
8–11 years
54
12+ years
47

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause decreased activity in dogs?
114 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 59 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased activity with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with decreased activity