Crust after Trilostane (Vetoryl) in dogs

The FDA has received 54 reports of crust in dogs after Trilostane. That is 0.5% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

54Reports

81%Marked serious

1.9%Recovered

15%Died or euthanised

46 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

3 6.3%

3–7 days

3 6.3%

1–4 weeks

13 27%

Over a month

29 60%

How the animals did

Recovered with lasting effects

1 1.9%

Still unwell when reported

10 19%

Died

2 3.7%

Euthanised

6 11%

Not known

35 65%

Problems reported at the same time

Hair loss

20 37%

Liver problems

14 26%

Weight loss

13 24%

Skin rash or irritation

12 22%

11 20%

11 20%

11 20%

10 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause crust in dogs?: 54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 46 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Crust with similar medicines

Crust after Levothyroxine 35 reports · 1.2% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with crust