Abnormal cytology after Trilostane (Vetoryl) in dogs

44 reports to the FDA describe abnormal cytology in dogs given Trilostane. That is 0.4% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

44Reports

80%Marked serious

6.8%Recovered

30%Died or euthanised

58 daysTypical onset

How soon it started

Same day

1 2.6%

1–2 days

1 2.6%

3–7 days

3 7.9%

1–4 weeks

9 24%

Over a month

24 63%

How the animals did

Recovered

3 6.8%

Still unwell when reported

12 27%

Died

1 2.3%

Euthanised

12 27%

Not known

16 36%

Problems reported at the same time

Hair loss

14 32%

Death

13 30%

Loss of appetite

13 30%

Skin rash or irritation

11 25%

11 25%

10 23%

8 18%

8 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause abnormal cytology in dogs?: 44 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 58 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal cytology with similar medicines

Abnormal cytology after Levothyroxine 35 reports · 1.2% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with abnormal cytology