Systemic disorder after Selamectin (Revolution) in dogs

The FDA has received 76 reports of systemic disorder in dogs after Selamectin. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

76Reports

17%Marked serious

24%Recovered

9.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

24 51%

1–2 days

8 17%

3–7 days

7 15%

1–4 weeks

5 11%

Over a month

3 6.4%

How the animals did

Recovered

17 22%

Recovered with lasting effects

1 1.3%

Still unwell when reported

13 17%

Died

5 6.6%

Euthanised

2 2.6%

Not known

38 50%

Problems reported at the same time

20 26%

16 21%

11 14%

9 12%

8 11%

Restlessness or agitation

7 9.2%

Wobbliness (ataxia)

7 9.2%

Behaviour change

7 9.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause systemic disorder in dogs?: 76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Systemic disorder with similar medicines

Systemic disorder after Ivermectin + Pyrantel (Heartgard Plus) 136 reports · 0.1% of its reports
Systemic disorder after Milbemycin Oxime + Spinosad (Trifexis) 404 reports · 0.3% of its reports
Systemic disorder after Moxidectin (ProHeart 6) 123 reports · 0.2% of its reports
Systemic disorder after Milbemycin Oxime + Praziquantel (Interceptor Plus) 21 reports · 0.1% of its reports
Systemic disorder after Milbemycin Oxime (Interceptor) 26 reports · 0.1% of its reports
Systemic disorder after Ivermectin (Heartgard) 32 reports · 0.3% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with systemic disorder