Systemic disorder after Moxidectin (ProHeart 6) in dogs

123 reports to the FDA describe systemic disorder in dogs given Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

123Reports

46%Marked serious

16%Recovered

24%Died or euthanised

Same dayTypical onset

How soon it started

Same day

59 61%

1–2 days

14 14%

3–7 days

6 6.2%

1–4 weeks

8 8.2%

Over a month

10 10%

How the animals did

Recovered

20 16%

Still unwell when reported

42 34%

Died

19 15%

Euthanised

11 8.9%

Not known

31 25%

Problems reported at the same time

42 34%

36 29%

32 26%

31 25%

26 21%

22 18%

17 14%

16 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause systemic disorder in dogs?: 123 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Systemic disorder with similar medicines

Systemic disorder after Ivermectin + Pyrantel (Heartgard Plus) 136 reports · 0.1% of its reports
Systemic disorder after Milbemycin Oxime + Spinosad (Trifexis) 404 reports · 0.3% of its reports
Systemic disorder after Milbemycin Oxime + Praziquantel (Interceptor Plus) 21 reports · 0.1% of its reports
Systemic disorder after Milbemycin Oxime (Interceptor) 26 reports · 0.1% of its reports
Systemic disorder after Selamectin (Revolution) 76 reports · 0.3% of its reports
Systemic disorder after Ivermectin (Heartgard) 32 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with systemic disorder