Hypoglycaemia after Selamectin (Revolution) in dogs

92 reports to the FDA describe hypoglycaemia in dogs given Selamectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

92Reports

35%Marked serious

11%Recovered

40%Died or euthanised

1 daysTypical onset

How soon it started

Same day

19 48%

1–2 days

11 28%

3–7 days

3 7.5%

1–4 weeks

1 2.5%

Over a month

6 15%

How the animals did

Recovered

10 11%

Still unwell when reported

14 15%

Died

35 38%

Euthanised

2 2.2%

Not known

31 34%

Problems reported at the same time

46 50%

40 43%

36 39%

33 36%

30 33%

27 29%

26 28%

20 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause hypoglycaemia in dogs?: 92 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoglycaemia with similar medicines

Hypoglycaemia after Ivermectin + Pyrantel (Heartgard Plus) 93 reports · 0.1% of its reports
Hypoglycaemia after Milbemycin Oxime + Spinosad (Trifexis) 147 reports · 0.1% of its reports
Hypoglycaemia after Moxidectin (ProHeart 6) 139 reports · 0.3% of its reports
Hypoglycaemia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 32 reports · 0.1% of its reports
Hypoglycaemia after Milbemycin Oxime (Interceptor) 52 reports · 0.2% of its reports
Hypoglycaemia after Ivermectin (Heartgard) 28 reports · 0.2% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with hypoglycaemia